010-88182880
當前位置：首頁 > 公司新聞 當前位置：首頁 > 公司新聞 干擾素基因刺激蛋白 (STING, TMEM173, MITA) 是一種跨膜接頭蛋白，它是細胞病原細胞漿 DNA 的天然免疫應答的一個關鍵組分 【1,2】。STING 是一種被發(fā)現(xiàn)主要在內質網(wǎng)中普遍表達的蛋白 【1】。在細胞漿 DNA 的刺激下，酶 cGAMP 合成酶 (cGAS) 會產(chǎn)生第二信使環(huán)-GMP-AMP (cGAMP) 【3,4】。cGAMP 結合并激活 STING 【3,4】。此外，通過 DDX41 和 IFI16 等核酸感應蛋白檢測細胞漿 DNA 會導致 STING 激活 【5,6】。激活后，STING 與 TBK1 轉位至核周內體，并在 Ser366（小鼠內為 Ser365）位點被 ULK1 磷酸化【7, 8】。TBK1 激酶磷酸化并激活 IRF-3 和 NF-κB，從而誘導 I 型干擾素和其他免疫應答基因 【1,2,7】。
關鍵詞：天然免疫，自身免疫病，腫瘤免疫
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6月新品列表
貨號
產(chǎn)品名稱
應用
反應性
Adhesion / ECM
86903T
COL5A1 (E6U9W) Rabbit mAb
WB, IP, IHC-Bond, IHC-P, IF-IC
H
94386SF
E-Cadherin (4A2) Mouse mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, M, R
10962S
FAT1 Antibody
WB
H, M, (R)
97174SF
NCAM1 (CD56) (123C3) Mouse mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H
68534S
Occludin (6B8A3) Rat mAb
WB, IF-F, IF-IC
H, M
20302T
Periostin (E5F2S) Rabbit mAb
WB, IP, IHC-P
H
Apoptosis
74860SF
Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb (BSA and Azide Free)
IHC-P, IF-IC, F
H, M
95696SF
Cleaved PARP (Asp214) (D64E10) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, Mk
Cell Cycle / Checkpoint Control
62548SF
Ki-67 (8D5) Mouse mAb (BSA and Azide Free)
IHC-P, IF-IC, F
H
60480SF
p21 Waf1/Cip1 (DCS60) Mouse mAb (BSA and Azide Free)
WB, IHC-P
H, Mk
46565SF
p53 (DO-7) Mouse mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H
41359SF
Phospho-Rb (Ser807/811) (D20B12) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, M, R, Mk
Chromatin Regulation / Nuclear Function
52626S
GATAD2B (E2G4R) Rabbit mAb
WB
H, M, R, Mk
73098S
GATAD2B (E4I8Y) Rabbit mAb
WB
H, M, R, Mk
85449S
JMJD7 (E8J8Q) Rabbit mAb
WB
H, R, Mk
87162S
PHF19 (E8P4D) Rabbit mAb
WB, IP, ChIP
H, M, R, Mk
65992S
PSPC1 (E7L8B) Rabbit mAb
WB, IF-IC
H, M, (R)
Cytoskeletal Signaling
62114S
CAPZA1 (E3U1G) Rabbit mAb
WB
H, M, R
10333S
CAPZB (E4H6C) Rabbit mAb
WB
H, M, R
56551S
DOCK5 (E6R9W) Rabbit mAb
WB, IP
H
46251S
Keratin 14 Antibody
WB
H, M, R
69319SF
α-Smooth Muscle Actin (1A4) Mouse mAb (BSA and Azide Free)
WB, IHC-P
H, M, R
Developmental Biology
72528S
Human EGF Recombinant Protein
-
-
87548S
Mouse FGF-basic/FGF2 Recombinant Protein
-
-
87179T
HIF-2α (E7K6E) Rabbit mAb
WB, ChIP
H
60770T
MITF (D5) Mouse mAb
IHC-P, IF-IC
H
42028S
Human PDGF-AA Recombinant Protein
-
-
25330S
RUNX3/AML2 (D6E2) Rabbit mAb?(Alexa Fluor??488?Conjugate)
F
H, M, R
81849S
RUNX3/AML2 (D6E2) Rabbit mAb?(Alexa Fluor??647?Conjugate)
F
H, M, R
50850S
TWIST1 (E2M5V) Rabbit mAb
IHC-P
M
Glucose / Energy Metabolism
0
?
?
40941S
IGF-II (E3F3N) Rabbit mAb
WB
H, M, R
Immunology and Inflammation
47359SF
CD3ε (D4V8L) Rabbit mAb (BSA and Azide Free)
WB, IHC-Bond, IHC-P
M
32814S
CD7 (E4G1Q) XP? Rabbit mAb
WB, IHC-Bond, IHC-P
H
32814T
CD7 (E4G1Q) XP? Rabbit mAb
WB, IHC-Bond, IHC-P
H
53986C
PathScan? Phospho-CrkL (Tyr207) Sandwich ELISA Kit
ELISA
H
49392S
DOCK2 (E7X1P) Rabbit mAb
WB, IP
H
87015S
Human GM-CSF Recombinant Protein
-
-
87791SF
Granzyme B (E5V2L) Rabbit mAb (Mouse Specific) (BSA and Azide Free)
WB, IHC-Bond, IHC-P, F
M
29881S
GUCY2C (E1Q6S) Rabbit mAb
WB, IP, IF-IC
H
37517S
GUCY2C (E6I2U) Rabbit mAb
WB, IP, IHC-P
H
50384S
IgA (N1CLA) Mouse mAb
IHC-Bond, IHC-P
H
33469S
IgG (RWP49) Mouse mAb
IHC-Bond, IHC-P
H
54059S
Human IL-1β Recombinant Protein
-
-
95742SF
IL-2Rα/CD25 (E9W2J) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-Bond, IHC-P, IF-F, F
M
98018S
Mouse IL-3 Recombinant Protein
-
-
64063S
Mouse IL-7 Recombinant Protein
-
-
79627S
Human IL-13 Recombinant Protein
-
-
84087S
Human β-NGF Recombinant Protein
-
-
74906S
OAS3 (E4X7Z) Rabbit mAb
WB
H
60847SF
PD-1 (EH33) Mouse mAb (IHC-Specific) (BSA and Azide Free)
IHC-Bond, IHC-P
H
39356SF
PD-L1 (405.9A11) Mouse mAb (BSA and Azide Free)
WB, IHC-P
H
24224SF
PD-L1 (Extracellular Domain Specific) (E1J2J?) Rabbit mAb (BSA and Azide Free)
WB, IHC-P
H
37908S
SERPINB9 (E9J8J) XP? Rabbit mAb
WB, IHC-P
H
37908T
SERPINB9 (E9J8J) XP? Rabbit mAb
WB, IHC-P
H
58551S
SERPINB9 (E9X9Z) Rabbit mAb
WB, F
H
88845SF
Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, M
73533SF
Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-Bond, IHC-P, IF-IC, F
H, M, R, Mk
51879SF
Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb (BSA and Azide Free)
WB, IHC-P, F
H, M
90947S
STING (E9X7F) Rabbit mAb
IF-F, IF-IC, F
H, M
16769S
Human TNF-α Recombinant Protein
-
-
24095S
Mouse TNF-α Recombinant Protein
-
-
87804S
Tox3 Antibody
WB
H
Infectious Diseases
19595S
SARS-CoV-2 2'-O-ribose Methyltransferase (E6N2C) Rabbit mAb
WB
Vir
93220S
SARS-CoV-2 3C-Like Protease (E9A1K) Rabbit mAb
WB
Vir
MAP Kinase Signaling
77955SF
Phospho-c-Jun (Ser73) (D47G9) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-F, IF-IC, F
H, M, R, Mk, Pg
62979SF
Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, M, R, Mk, Mi, Pg, Sc
45899SF
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP? Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC, F
H, M, R, Hm, Mk, Mi, Dm, Z, B, Dg, Pg, Sc
55773SF
Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb (BSA and Azide Free)
WB, IHC-P, IF-IC
H, Mk
58328SF
Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb (BSA and Azide Free)
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